The South Bay region borders on San Diego Bay and the Pacific Ocean.

Nature preserves in the South Bay region include the San Bay region include the San Diego Bay National Wildlife Refuge and the Otay Mountain Wilderness.

The Naval Base San Diego is located in the South Bay. It is the second largest surface ship base of the United States Navy. It is a major employer with more than 24,000 military personnel and over 10,000 civilians.

Other regions of San Diego County include North County and East County.

Chula Vista Bayfront

The Chula Vista Bayfront is a large planned development on the San Diego Bay waterfront in Chula Vista which is in South Bay San Diego. The development started in the 1970s and is one of the largest waterfront projects in the entire United States. The development includes hotels, restaurants, condominiums, and a large convention center which attracts visitors from all over San Diego County and Imperial County.

The Living Coast Discovery Center

The Living Coast Discovery Center, also referred to as the Chula Vista Wildlife Preserve, and the Chula Vista Nature Center, was established in 1987. It is located in the South Bay region of San Diego. There are several exhibits including , the Turtle Lagoon, the Shark and Sting Ray Touch Pool, Eagle Mesa, Shorebird Aviary, Native Plant Gardens, and several others. Living Coast Discovery Center is a significant tourist attraction and provides local school children with educational opportunities.